This volume is the expression of seven-year scientific findings built within the INTEGRO UAD International Meetings convened at the University of Florence while the development of the collection of chapters reflects interpretations of the most pressing issues and necessary perspectives required to frame changes in planning and design. In putting together this collection, it is aimed to better understand questions, prospects, reflections and rules on improving urban strategies and tactics in balancing the needs of nature and the built form to deliver a place. Discussions, debates, and stated considerations can now inspire to give a formal and comprehensive international attention to the transformation of urban heritage including ecological and sustainable design knowledge.